Run Away with Me is about knowing someone your entire life but never finding the courage to tell them how you truly feel about them until it is too late. This song is a love ballad that tells the story of childhood friends who grew apart and looking back on that experience wishing you told them your true feelings. It is about the other person being married and having a different life without you in it anymore, and wishing you could confront them and tell them your true feelings that you have had for them throughout the years.